From the following, which medication is not approved for weight management due to low efficacy?

From the following, which medication is not approved for weight management due to low efficacy?

• A. Phentermine
• B. Lisdexamfetamine
• C. Orlistat
• D. Liraglutide

Answer: (B)

Not all medications that affect weight are approved for weight management; regulators require meaningful, durable weight loss with acceptable safety. Lisdexamfetamine is not approved for obesity treatment because the evidence for sustained, clinically important weight reduction is lacking, and its risks (stimulant effects, misuse potential) outweigh a weight-management benefit. In contrast, phentermine, orlistat, and liraglutide have approvals for weight management based on demonstrated efficacy and safety in the relevant populations.

Not all medications that affect weight are approved for weight management; regulators require meaningful, durable weight loss with acceptable safety. Lisdexamfetamine is not approved for obesity treatment because the evidence for sustained, clinically important weight reduction is lacking, and its risks (stimulant effects, misuse potential) outweigh a weight-management benefit. In contrast, phentermine, orlistat, and liraglutide have approvals for weight management based on demonstrated efficacy and safety in the relevant populations.